Overall, the use of titanium dioxide by manufacturers is essential for various industries, providing valuable properties and benefits for a wide range of products. As technology advances and new applications are discovered, the demand for titanium dioxide is expected to continue to grow. Manufacturers will need to adapt and innovate to meet the evolving needs of their customers while ensuring the safety and sustainability of their products.

Lithopone Market Outlook - 2020–2027

Calcium carbonate is a naturally occurring mineral that is found in rocks and minerals such as calcite, aragonite, and limestone. It is commonly used in industries such as paint, paper, plastics, and rubber as a filler and pigment. The manufacturing process of calcium carbonate involves extracting the mineral from quarries or mines, crushing and grinding it into a fine powder, and then purifying it through various chemical processes.

You can find titanium dioxide in products like:

For a review published in 2023 in the journal Environmental Pollution, researchers examined E171 as a possible factor promoting obesity-related metabolic disorders. Because gut microbiota play an important role in immune function maintenance and development, and because titanium dioxide as a food additive has been shown to alter gut microbiota, researchers wanted to review “the dysregulations along the gut microbiota-immune system axis after oral TiO2 exposure compared to those reported in obese or diabetic patients, and to highlight potential mechanisms by which foodborne TiO2 nanoparticles may increase the susceptibility to develop obesity-related metabolic disorders.” The study authors discovered recurrent changes in the gut microbiota composition when exposed to titanium dioxide nanoparticles, with an imbalance of intestinal symbiotic microbiota. These changes and imbalances were also reported and played a role in the development of obesity, the authors wrote. This highlights “foodborne TiO2 nanoparticles as an endocrine disruptor-like chemical promoting obesity-related disorders,” the authors concluded.

In addition to quality and reliability, r 996 titanium dioxide suppliers also offer competitive pricing, ensuring that customers get value for their money. By sourcing products from these suppliers, businesses can save costs without compromising on the quality of the raw materials used in their production processes.

Below 20% substitution, it is recommended to replace 1 kg of TiO2 with 1 kg of lithopone supplier.  

In a study published in the journal Environmental Toxicology and Pharmacology in 2020, researchers examined the effects of food additives titanium dioxide and silica on the intestinal tract by grouping and feeding mice three different food-grade particles — micro-TiO2, nano-TiO2, and nano-SiO2.  With all three groups, researchers observed changes in the gut microbiota, particularly mucus-associated bacteria. Furthermore, all three groups experienced inflammatory damage to the intestine, but the nano-TiO2 displayed the most pronounced changes. The researchers wrote: “Our results suggest that the toxic effects on the intestine were due to reduced intestinal mucus barrier function and an increase in metabolite lipopolysaccharides which activated the expression of inflammatory factors downstream. In mice exposed to nano-TiO2, the intestinal PKC/TLR4/NF-κB signaling pathway was activated. These findings will raise awareness of toxicities associated with the use of food-grade TiO2 and SiO2.”